Seattle will host the first leg of the series in early March, and visit Santos for the second game. Toronto FC will host the first fixture of its series with L.A., with the return leg in California.
The first legs will be March 6-8, and the return games are March 13-15. In the other match-ups, Monterrey plays Morelia in an all-Mexican pairing, and Mexico side UNAM will play El Salvador side Isidro Metapan.
The two-legged semifinal series will start in late March with the first match, and the second leg is the first week of April. The two-legged final will be on two dates in mid-to-late April.