Mauricio Pinilla and Abel Hernandez scored, game Serie A losing streak with a 2-0 win over Lecce on Thursday.
Pinilla converted a penalty kick in the 27th minute to open the scoring, and Hernandez added the clincher in the 77th minute.
Even with three losses this season, Palermo is just three points off the pace of undefeated leaders Juventus. Palermo has four wins and a tie, while Juve is on 16 points with four wins and four draws.
Lecce lost for the sixth time - a Serie A high - through eight matches, and is just one point off the bottom and winless Cesena.