The 22-year-old Taiwanese star closed with a 6-under 66 at Sunrise for a five-stroke victory over Spain's Azahara Munoz and South Korea's Amy Yang.
"I play really, really good today. I was bogey free," Tseng said. "I wish this year would go on forever so I could win more. But I can always get better."
Tseng finished at 16 under and earned $300,000 for her seventh LPGA Tour victory of the season to increase her tour-leading total to $2,873,629. She donated $100,000 to the Taiwan Golf Association to support junior golf.
"It is a long road to develop and groom a golfer," Tseng said. "Young golfers need as much support as possible to help them compete with the best from the rest of the world, in addition to their own commitment and hard work. I hope I can set an example so more people will follow suit to help chip in and contribute to this cause in an attempt to bring out more young talents."
Tseng won her first four events this year, taking the Taiwanese tour's Taifong Ladies and sweeping the Australian Women's Open and Ladies Masters before opening the LPGA Tour season with a victory in the LPGA Thailand.
The LPGA Tour player of the year for the second straight season, the top-ranked Tseng won major titles this summer in the LPGA Championship and Women's British Open and has 12 victories in four seasons on the tour.
After opening with rounds of 68, 71 and 67 to take a two-stroke lead into the final round, Tseng birdied the par-3 second and reached 14 under with birdies on the par-5 sixth and par-4 seventh and eighth holes.
She parred the next seven holes, birdied the par-3 16th, increased her lead to four strokes with a par on the par-4 17th and birdied the par-5 18th.
"So exciting, especially winning this tournament in front of all the big crowd from Taiwan," Tseng said. "I really, really appreciated them coming today. It was a really, really huge crowd and all the people, I think all the players and all the people from the other country very enjoy this week.'
Yang finished with a 67, and Munoz had a 68.
American Morgan Pressel shot a 65 — the best round of the week in the inaugural tournament, to tie for fourth with Sweden's Anna Nordqvist (71) at 9 under.