The Blues won their second game in two nights, after beating Carolina in overtime on their home ice. They didn't arrive in their Philadelphia hotel until after 3 a.m. and skipped the morning skate.
The Blues hardly looked fatigued after OT and a long night of travel. They pounced on the Flyers and Huskins scored only 1:48 into the game.
Ilya Bryzgalov had his second straight off game in net for the Flyers. After allowing five goals in a loss to Washington, Bryzgalov allowed two on the first eight shots.
Forget the Cardinals in the World Series. The Blues were the St. Louis team connecting on offense.
St. Louis center Jason Arnott set up the first goal when he beat Claude Giroux off a faceoff in Philadelphia's zone. Huskins took a soft shot from the point once the puck came his way, but it was enough for the left-hander to beat Bryzgalov for the early goal.
The Blues made it 2-0 on a nice give-and-go from Carlo Colaiacovo to Oshie. Bryzgalov bit on Colaiacovo's give, allowing Oshie to easily pound in his first goal of the season for a 2-0 lead with 9:56 left.
That made it two goals on eight shots for the Blues. The Flyers fans, who saw the home team get routed on Thursday, quickly lost their patience and booed.
Flyers coach Peter Laviolette called a 30-second timeout and unloaded on his team for their second straight sluggish start. Trying to spark the offense, Laviolette switched around line combinations.
He mixed them up at Friday's practice, only to scrap them and try new combos against St. Louis.
Briere was off to a slow start with only one goal in the first six games. He showed a sign of snapping out of the funk when he snapped a wrister from the circle high over Elliott's glove 56 seconds into the second to make it 2-1.
All that momentum against Elliott, back in net a night after holding off the Hurricanes, was short lived.
They could never sustain any more serious attacks against Elliott.
The Flyers caught a break late in the third when a replay review showed Carle's puck crossed the line before it was swiped away by a St. Louis defenseman to make it 3-2. The crowd roared when the review went in Philadelphia's favor and momentum could have shifted on home ice.
But the energy was sucked out of the building when Matt D'Agostini backhanded a power-play goal just over a minute later for a 4-2 lead.
The Blues had been an NHL-worst 1 for 25 on the power play entering the game. D'Agostini made the Flyers pay with Scott Hartnell in the box for crosschecking.
The Blues were the team with more jump all game. Late in the second period, Colaiacovo knocked in a loose puck late off a rebound for a 3-1 lead. Like Oshie, it was his first goal of the season.
Colaiacovo played for the second straight night after missing five games with an upper-body injury suffered in the season opener.
The Blues could have another player on the injury list after forward David Backes left in the second period with an upper-body injury. He was plowed on a clean hit by Flyers defenseman Chris Pronger and was down on the ice for a bit before skating off on his own power.
Notes: This is the only game this season between the two teams. ... The Blues earned points in their past five games against the Flyers.