Addai did not practice Wednesday or Thursday because of a hamstring injury, which forced him to miss last week's game against Cincinnati. It also forced him to leave the Colts' Week 5 matchup with Kansas City.
Addai, 28, has rushed for 249 yards and a touchdown in five games this season for the Colts, who carry an 0-6 record into Sunday night's game in New Orleans.
Additionally, Indianapolis wide receiver Anthony Gonzalez did not practice Friday because of a groin injury that limited him in Thursday's session. He is listed as questionable, as are quarterback Kerry Collins (concussion) and tackle Anthony Castonzo (ankle).