It will be the first time in the 20-year history of the non-official event that women will team up against the men.
Defending champions Mark O'Meara and Nick Price will be back for the competition on November 7. Nick Faldo and Rocco Mediate will pair up and the duo of Jerry Kelly and Zach Johnson will round out the field.
For Sorenstam, this will be her first professional competition since the 2008 LPGA Tour's season-ender, the ADT Championship. Sorenstam teed it up with the men previously when she participated in the 2003 Colonial on the PGA Tour.
The competition will be broadcast December 24-25 on NBC.