The seventh-seeded Kirilenko was leading Carla Suarez Navarro 7-6 (7-5), 3-6, 3-0 when the Spaniard retired due to a right ankle injury on the indoor hardcourts at CK Sportcenter Kockelscheuer.
Up next for Kirilenko will be veteran Czech left-hander Iveta Benesova.
In other Day-1 action, Austrian Tamira Paszek pasted Russian Ekaterina Makarova 6-2, 6-2, while Spaniard Anabel Medina Garrigues double-bageled helpless wild card and Luxembourg's own Anne Kremer 6-0, 6-0 and Benesova overcame France's Pauline Parmentier 3-6, 6-3, 6-2. Kremer turned 36 on Monday.
This week's top seeds are Belarusian star Victoria Azarenka and Russian Anastasia Pavlyuchenkova. Third seed and 2009 runner-up Sabine Lisicki of Germany pulled out of the draw on Monday, citing an illness.
The 2011 Luxembourg titlist will collect $37,000.