Calgary, AB – Helped by a four-goal second period, the 3, in the home opener for the Flames.
Tyler Kennedy, Matt Niskanen, Craig Adams, Jordan Staal and Evgeni Malkin netted the five goals for the Penguins, who are off to a 2-0 start after defeating the Canucks, 4-3, in a shootout on Thursday night.
Marc-Andre Fleury stopped 16-of-19 shots.
Mark Giordano made a move to elude a defender and then set up Glencross with a beautiful cross-ice pass as he one-timed it home at the 15:32 mark of the first period.
Just 1:04 into the second stanza, Kennedy wristed one through Kiprusoff's pads to tie the game.
Niskanen followed his own shot and scored when his initial chance ricocheted right back to his stick as the Penguins took a 2-1 lead 6:04 into the second period.
Adams found a loose puck in the crease and lit the lamp when he deflected his shot off of Calgary's Anton Babchuk to make it 3-1.
Malkin kept chipping away at the puck in front of Kiprusoff until it slipped past him as the Penguins took a 4-1 advantage 13:04 into the second.
Bourque found the back of the net midway through the third frame to make it a two-score game.
Niklas Hagman found Jokinen from behind the net as Jokinen slapped the one- timer past Fleury to pull the Flames within a goal with 3:37 left.
Staal scored an empty-netter with five seconds remaining in the game.
Pittsburgh has won its last five games against the Flames.