The Eagles, who dropped to 1-3 after its 24-23 loss to San Francisco, lost Cole for several weeks due to a calf strain he sustained Sunday. Peters suffered a hamstring injury during the game.
Neither player has practiced all week.
Peters, a four-time Pro Bowl selection, has been the Eagles' left tackle since he was acquired from Buffalo in 2009. Cole, a two-time Pro Bowl pick, has three sacks this season.
Tapp hasn't played since recording a sack and three tackles in week one against St. Louis. He's listed as probable. Parker is listed as questionable with an ankle injury. He's missed the last two games.