Michael Vick got a helping hand from an official after a hard shot knocked him to the ground and left him with a broken right hand.
He didn't get the call.
Manning threw four touchdown passes, including two to Victor Cruz, and the Giants beat the Eagles 29-16 Sunday.
Vick started despite suffering a concussion in last week's 35-31 loss at Atlanta. He left this one in the fourth quarter after helping the Eagles overcome a 14-0 first-quarter deficit to take a 16-14 lead.
It's uncertain how long the left-handed Vick will be out. He'll have a CT scan Monday.
Vick blasted the officials after the game, saying he wants to be treated like other quarterbacks.
"At some point something catastrophic is going to happen," Vick said. "Not to blame the refs or say that it was their fault, it's just one of those unfortunate situations and I just think more precautions should be taken when I'm inside the pocket. If you look at all the replays, I'm on the ground every time and it's unfortunate for myself and it's unfortunate for my team and I'll be lying if I said I wasn't, if I were to sit here and say I wasn't frustrated right now because of that."
Vick got hurt on a hit from Chris Canty after completing a 23-yard pass to Jeremy Maclin in the third quarter. It appeared on replays that Canty hit Vick in the facemask with his helmet. Vick sat on the ground and lifted his helmet off slightly before getting helped up by a teammate and an official.
"There's no reason for me to go into a big dissertation about why I'm not getting the calls," Vick said. "The refs, they have to do their job as well. I even mentioned it in training camp to the refs when we had our little meeting, so just for precaution. But hey, I don't know."
Without their Pro Bowl quarterback, the Eagles (1-2) hardly look like the "Dream Team" that entered the season with Super Bowl-or-bust expectations.
Manning threw a pair of TD passes in the fourth quarter to rally New York. The Giants (2-1) have won two in a row and snapped a six-game losing streak against their division rivals.
"It's always good to beat those guys, especially here," Manning said. "They have good players and we knew we had to come in with the same game plan as last year and just finish it this time."
In their previous meeting at the Meadowlands last December, the Eagles rallied from a 21-point deficit with 8:17 left, and won 38-31 on DeSean Jackson's 65-yard punt return for a touchdown on the last play.
The teams traded a lot of trash talk in the offseason and during the week. The Giants backed it up.
"I think I responded today," Giants safety Antrel Rolle said. "I'm not scared of anyone on the field. I thing it's more mental than physical. They tried to get in my head sticking their hands in my face, blocking me after the play, but if they want to fight, I'll fight anyone, but in between the lines, I'm too smart to get thrown out of the game."
Manning threw for 254 yards, and Ahmad Bradshaw ran for 86 and had 53 more receiving, including a TD. Filling in because Mario Manningham and Domenik Hixon are out, Cruz had three catches for 110 yards and his first two career scores.
Aaron Ross, who was benched in the second half of New York's win over St. Louis last Monday, had two interceptions that led to 14 points.
LeSean McCoy had 128 yards rushing and one TD for Philadelphia, which has blown two fourth-quarter leads in consecutive games.
After McCoy was stopped for a 3-yard loss by Michael Boley on fourth-and-1 from the Giants 43, Manning drove New York in for the go-ahead score. He tossed a 28-yard TD pass to a well-covered Cruz to put the Giants up 20-16. Jacobs ran in the 2-point conversion to make it 22-16.
"It means the world to me because a lot of people were saying our receivers were down and who would step up and I was happy to be that guy that stepped up to help my team," Cruz said.
Mike Kafka replaced Vick on the ensuing possession and Ross intercepted his first pass. Manning connected with Bradshaw for an 18-yard TD pass to put the game away.
Vick finished 16 of 23 for 176 yards and one interception. He ran for 31 yards.
The Eagles dominated time of possession by a nearly 3-1 margin throughout the first three quarters, but didn't take the lead until the final minute of the third when Alex Henery kicked a 21-yard field goal.
It was a disappointing end to a drive that began at the 10 and stalled at the Giants 1. The Eagles had a first down at the 2 and failed on four runs to get it in. McCoy didn't get one of the handoffs.
Vick left the game for X-rays on his right hand after that drive and was temporarily replaced by Kafka. But he returned during a timeout while Kafka was in the huddle and played one more drive before going to the bench.
Steve Smith made a crucial mistake on the first ball that came his away against his former team. Smith left the Giants for Philadelphia and returned ahead of schedule from knee surgery to be ready for Week 1. Vick's third-down pass on Philadelphia's first drive hit Smith in the hands and bounced in the air to Ross, who caught it at the Giants 8. Ross returned the interception 19 yards, and Manning needed six plays to lead New York into the end zone.