Duncan also had three RBI in the opener of the twinbill, an 8-2 Cleveland win.
Carlos Santana went 2-for-4 with two runs scored while Lonnie Chisenhall and Ezequiel Carrera each had two hits and an RBI for the Indians, who have won four straight to move two games over .500.
"Long but productive day," said Cleveland manager Manny Acta. "Our offense really stepped up today and Duncan was fantastic. We were in a big hole today and we crawled out of it."
Mitch Talbot pitched 5 1/3 innings in the start for Cleveland, giving up six runs on nine hits with four walks. Nick Hagadone (1-0) pitched a perfect seventh inning for the first win of his career.
Scott Diamond was tagged for four runs on six hits over 5 1/3 innings in the start for Minnesota. Jose Mijares (0-2) got the loss.
The Indians were trailing, 6-0, entering the home sixth, but cut into their deficit with five runs in the frame.
With two on, Duncan brought home one with a single and Chisenhall followed with an RBI double. Alex Burnett then took the hill and Lou Marson greeted him with a single to plate another run. Cord Phelps then brought home one with a groundout and Carrera's single made it a 6-5 game.
Duncan's two-run double to left in the seventh gave the Indians a 7-6 lead.
Butera brought home two more with a double in the sixth and later scored when Plouffe lofted a sac fly to left for a 6-0 advantage.
Duncan has 44 RBI on the season...Cleveland is 44-36 at home while Minnesota is a woeful 29-51 as the guest...Cleveland has won 12 of the 17 games with Minnesota this season...Cleveland batted 5-for-12 with runners in the scoring position.