Kenny Stills reached high to grab a 37-yard touchdown pass from Landry Jones midway through the fourth quarter for the tiebreaking score, and Oklahoma's defense made the lead stand as the top-ranked Sooners beat No. 5 Florida State 23-13 on Saturday night.
Javon Harris picked off two passes for the Sooners (2-0), who forced three turnovers and harassed both Florida State quarterbacks all night.
The Seminoles (2-1) played the final 20 minutes without starting quarterback E.J. Manuel, who left in the third with a left shoulder injury.
Backup Clint Trickett kept the Seminoles in it. He hooked up with freshman Rashad Greene for a 56-yard touchdown on a third-and-28 with 9:32 left in the fourth quarter to tie the game at 13.
But on the next possession, Jones went deep down the sideline to the 6-foot-1 Stills, who easily outleaped the 5-8 Greg Reid for the touchdown.