Wayne Rooney scored his second successive 0 win over Bolton at the Reebok Stadium.
United stormed out to a 3-0 lead in the opening 25 minutes as Javier Hernandez opened his account after four minutes, while Rooney scored a pair of goals six minutes apart to extend the advantage to 3-0.
Hernandez bagged his second goal in the 57th minute and Rooney completed his hat trick 11 minutes later to cap a dominating performance from United, which has won its first four games this season.
Rooney scored a hat trick in United's 8-2 romp over Arsenal last time out, and after Hernandez found the net from close range in the fourth minute, Rooney scored his first goal after being set up by Phil Jones.
Jones helped Rooney tally his second goal in the 25th minute with a nice run that resulted in Rooney firing home a loose ball from 14 yards.
Hernandez collected his second goal of the contest by knocking home a deflected shot from Michael Carrick, while Rooney's third goal was set up by Nani, who squared the ball to England international and watched him curl his shot inside the left post from 20 yards.
Manchester City 3, Wigan 0
Manchester, England - Manchester City's perfect start to the season continued on Saturday as Sergio Aguero tallied a hat trick in a 3-0 win for City over Wigan at the Etihad Stadium.
David Silva played provider on the first goal in the 13th minute on a nice counter-attack move, while Aguero's second tally came after 63 minutes with Samir Nasri's through ball setting it up.
Aguero and Silva combined again on the third goal six minutes later, with the Argentina international completing his hat trick by latching onto a through ball from Silva and slotting his shot past goalkeeper Ali Al Habsi.
Arsenal 1, Swansea City 0
London, England - Arsenal grabbed its first win of the season on Saturday at the Emirates Stadium as Andrei Arshavin scored late in the first half to hand the Gunners a 1-0 win over Swansea City.
It wasn't a vintage performance from Arsenal, but after collecting one point from its first three games, maximum points will be a welcome result.
Swansea still has yet to score this season in four league games, but the Swans left London without any points only after a terrible error in defense handed the hosts their lone goal.
Goalkeeper Michel Vorm attempted to roll the ball out, but it struck defender Angel Rangel, leaving Arshavin with an open net from a tight angle that allowed the Russian to tuck the ball inside the far post.
Stoke City 1, Liverpool 0
Stoke-on-Trent, England - Liverpool stumbled to its first defeat of the campaign on Saturday as a first-half penalty kick from Jonathan Walters handed Stoke City a 1-0 win over the Reds.
Stoke's 'keeper, Asmir Begovic, was much busier throughout the match, but he made a number of crucial saves in the second half to preserve the win, which lifts the Potters into fourth place with eight points from four games.
Chelsea 2, Sunderland 1
Sunderland, England - Chelsea collected three more points on Saturday at the Stadium of Light as the Blues secured a 2-1 win over Sunderland.
John Terry's first-half goal gave the visitors the lead, and it was doubled early in the second half by Daniel Sturridge, with the Black Cats pulling a goal back in stoppage time through substitute Dong-Won Ji.
Chelsea has won its last three games to remain within two points of the league lead, while Sunderland has managed two points from four games this season.
Everton 2, Aston Villa 2
Liverpool, England - A goal in the 83rd minute from Gabriel Agbonlahor kept Aston Villa unbeaten through four games as the Villains salvaged a 2-2 draw with Everton at Goodison Park.
Leon Osman gave the Toffees the lead at halftime with a goal in the 19th minute, but Stiliyan Petrov canceled it out in the 63rd with a goal for the visitors.
Leighton Baines restored Everton's lead from the penalty spot six minutes later, but Agbonlahor tallied his second goal of the campaign seven minutes from time, giving Villa three draws and a win from four games, while Everton has earned four points from three matches.
Tottenham 2, Wolverhampton 0
Wolverhampton, England - Tottenham climbed off the bottom of the league table on Saturday with a 2-0 triumph over Wolverhampton at Molineux.
Emmanuel Adebayor scored the opening goal in his Tottenham debut after 66 minutes as he was set up by another new signing, Scott Parker.
Jermain Defoe secured the win 10 minutes from time for Spurs when he played a one-two with Niko Kranjcar before firing a shot past goalkeeper Wayne Hennessey.
The loss is the first of the season for Wolves, while Tottenham had lost its first two games by a combined score of 8-1 prior to Saturday's win.