E.J. Manuel threw for 252 yards and two 0 victory over Monroe at Doak Campbell Stadium.
Manuel finished 22-of-34 with one interception for the Seminoles (1-0), who are looking to build off a 10-4 record in 2010 which included an ACC Atlantic Division title and Chick-fil-A Bowl triumph over South Carolina.
"The first few drives I had some jitters, but then finally settled down and sat in the pocket and delivered the ball like I do in practice," Manuel said. "It will definitely be something I work on this week as we look ahead to Charleston Southern."
Greg Dent, Bert Reed and Rashad Greene each recorded a TD reception, while Devonta Freeman added a rushing score in the whitewash.
Kolton Browning ended 11-of-19 for 85 yards and one pick for the Warhawks (0-1), who were limited to 191 yards of total offense.
The lone score of the opening quarter came when Manuel hit Reed for a nine- yard score to cap FSU's third drive of the contest.
The Seminoles got untracked in the second quarter, going 87 yards in 17 plays and taking a 10-0 lead on a 24-yard field from Dustin Hopkins.
Despite a Darius Prelow interception at the goal line on FSU's ensuing possession, the Warhawks saw their ensuing drive halted when Lamarcus Joyner picked off Browning deep in Seminoles territory.
An 84-yard march ensued and it was 17-0 for the home squad after a 50-yard Manuel-to-Dent hook-up.
Freeman's one-yard run put the exclamation point on a 66-yard drive in 14 plays for a 24-0 game and proved to be the lone tally of the third quarter.
Hopkins added a 23-yarder in the fourth, then Clint Trickett used his first career passing attempt to hit Greene for a 23-yard strike with less than seven minutes to play which capped the scoring.
Florida State produced 372 yards of total offense...Rodney Smith led all Seminole receivers with six catches for 78 yards...Je'Ron Hamm led Louisiana- Monroe with 22 yards on a pair of grabs...Reed posted four receptions for 43 yards...Both schools are in action next Saturday, as FSU hosts Charleston Southern and ULM welcomes Grambling.