Seimone Augustus scored 20 points, Maya 61, to clinch the Western Conference title.
The Lynx secured the franchise's first regular season West title after capturing their fifth straight win and 16th in their last 18 games. As the top seed, they will have home court advantage through the conference playoffs.
Minnesota finished 4-0 against San Antonio this season, including an 85-75 win on Friday in the first game of a home-and-home.
All of San Antonio's highest scorers came off the bench -- Roneeka Hodges scored 12 points and Jia Perkins and Tully Bevilaqua both had 10. The Silver Stars have lost six in a row.