The 26-year-old Dominican hit a paltry .220 with eight doubles, one triple and drove in seven runs over 85 games this season, his fifth in the majors.
In 398 games with the Cubs and Baltimore since 2007, Pie batted .249 with 17 homers, 44 doubles, 13 triples and 97 RBI.
The O's also recalled outfielder Matt Angle from Triple-A Norfolk and selected the contract of infielder Jake Fox from the Tides.
Fox spent 19 games with Baltimore earlier in the season, totaling two homers, two doubles and four RBI while hitting .188.
Angle, 25, made his major-league debut with the Orioles on July 17 but went hitless in seven at-bats over two games. He hit .272 and stole 27 bases in 107 games for Norfolk this year.