Wade LeBlanc pitched into the sixth inning run homer in San Diego's 4-3 win over Florida.
Will Venable doubled and scored twice for the Padres, who have taken the first two contests of this four-game series. They're 5-0 against the Marlins this season and have captured 11 of the past 13 meetings.
LeBlanc (2-2) allowed six hits and three runs over 5 1/3 innings to win his second straight start. Heath Bell walked John Buck to start the ninth, but retired the next three batters to notch his 34th save. Mike Cameron flied out to the warning track in center to end the game.
Jose Lopez doubled three times and recorded an RBI for the Marlins, who went 1-for-12 with men in scoring position and lost for the sixth time in seven contests.
Chris Volstad (5-10) fanned seven batters, but surrendered six hits and four runs over five frames. He's winless in his last four outings.