Sam Bradford completed 7-of-12 passes for 45 10, in preseason action.
A.J. Feeley connected on 10-of-14 passes for 100 yards for the Rams, who went 7-9 last season. Thaddeus Lewis completed 3-of-5 passes for 28 yards.
Tight end Lance Kendricks, the team's second-round draft choice, caught five passes for 47 yards and a score.
With Manning on the physically unable to perform list due to an offseason neck procedure, Curtis Painter lined up under center for Indianapolis. Painter completed 3-of-6 passes for 55 yards and an interception.
Dan Orlovsky connected on 4-of-10 passes for 111 yards, a touchdown and two interceptions for the Colts, who went 10-6 last season and lost to the Jets in the Wild Card round.