Nene, Chris Andersen, Ty Lawson and J.R. Smith had 14 points apiece for the Nuggets, who won for the fourth time in five games since completing the blockbuster trade that sent Carmelo Anthony to the New York Knicks.
The 40-point margin of victory surpassed Denver's previous high this season, a 34-point win against on Phoenix on Jan. 11.
Arron Afflalo, the only Nugget to play in all 62 games, rolled his ankle driving to the basket in the first quarter but returned. With a little more than five minutes to go in the third quarter, Afflalo was fouled hard when Gerald Henderson barreled into him on another drive to the basket.
Nuggets coach George Karl had seen enough by then, and with the game well in hand, had Afflalo take the rest of the night off.
Trailing by 16 at the half, the Bobcats scored eight of the first 10 points in the third quarter, starting with a 20-foot jumper by Stephen Jackson, to cut the deficit to 64-54.
But the Nuggets answered with an 8-2 run, including successive dunks by Nene and Chandler to build their lead back to 72-56 with 6:56 left in the third quarter. When Andersen closed out Denver's third quarter scoring on a dunk off a pass from Smith, the Nuggets had built their lead to 91-67 going into the fourth quarter.
Charlotte was outscored 29-13 in the final period.
The Nuggets set the tone for the game early, leading by 18 points in the second quarter and going in front 62-46 at halftime. Chandler and Andersen each had 10 points in the first half.
NOTES: Bobcats GM Rod Higgins said they plan to re-sign F Dominic McGuire and will sign G Garrett Temple of the NBA Development League to a 10-day contract. C Sean Marks will be waived to make room on the 15-man roster. McGuire was let go last week after the Bobcats' two trades left them with 18 players. ... C Timofey Mozgov played the final 1:53 of the second quarter in his first action as a Nugget since being included in the three-team, 13-player trade that sent Carmelo Anthony to New York. Kosta Koufos, who also came to Denver in the trade, made his first appearance as a Nugget late in the fourth. ... Chandler has scored at least 10 points in each of his four games as a Nugget. ... Charlotte's Stephen Jackson was held to seven points after scoring at least 30 in his previous two games.