It was the second straight shutout for the Tigers, who opened their exhibition season with a 4-0 win over the Blue Jays on Saturday.
The unearned run came off Henderson Alvarez in the sixth inning after a leadoff single by Andy Dirks, a bunt by Will Rhymes and a throwing error.
Detroit starter Brad Penny worked two innings and Max Scherzer followed with two hitless innings. Joaquin Benoit got the win after pitching the sixth inning for Detroit. Brayan Villarreal pitched the ninth for a save.
Toronto starter Mark Rzepzcynski also pitched two hitless innings.
Dirks had two of the Tigers' four hits.