Brandon Barnes scored 14 points and Josh Slater added 10 points and 12 assists as Lipscomb defeated South Carolina-Upstate 71-52 on Thursday night.
The Bisons (16-10, 11-6 Atlantic Sun Conference) trailed 19-18 with 6:43 left in the opening half before going on a 16-2 run, capped by a Jordan Burgason 3-pointer, to take a 34-21 lead with just over a minute left to play.
Lipscomb led 53-44 with 8:34 remaining and scored nine straight points to increase its lead to 62-44 with 7:01 to go.
Burgason and Adnan Hodzic each added 11 points for the Bisons, who shot 56.3 percent from the floor (27 of 48), including 50 percent from 3-point range (9 of 18).
Ricardo Glenn and Torrey Craig each had nine points and six rebounds for the Spartans (4-23, 3-14), who have lost four straight and 17 of their past 19.
The Bisons outrebounded USC Upstate 37-27.