The Pistons led by 10 midway through the fourth quarter, but allowed Darren Collison to tie the game with 15.4 seconds left. Prince had the ball in the final seconds of regulation with a chance to win it, but didn't get a good shot off or the foul he wanted from the officials.
Prince caught an airballed shot by teammate Ben Gordon and dunked, giving Detroit a six-point lead with 1:34 left in overtime.
The Pistons had lost three straight. The Pacers lost on consecutive nights after winning seven of eight.
The Prince-led Pistons trailed only in the opening minute of regulation and led by 11 after the first quarter. They were ahead by as much as 12 points and had a 92-82 lead in the fourth quarter.
Instead of crumbling and losing a season-high fifth straight at home, Detroit regrouped for the extra period well enough to outscore the Pacers 11-5 to get a much-needed win going into the All-Star break.
NOTES: Pistons owner Karen Davidson says she's cautiously optimistic the sale of the team will be completed soon. California billionaire Tom Gores have been negotiating exclusively with the Pistons. ... Indiana's Jeff Foster missed the game with an ankle injury and Richard Hamilton was held out with a groin injury. ... Detroit beat Indiana for the first time since Dec. 12, 2008, snapping a six-game skid.