Jasmine Thomas scored 17 points, Krystal Thomas had 12 points and 12 rebounds, and No. 5 Duke routed Wake Forest 82-39 on Friday night.
Allison Vernerey added 12 points for the Blue Devils (22-2, 8-1 Atlantic Coast Conference).
They bounced back from a loss to one instate rival by overpowering another. Duke never trailed, held a 52-31 rebounding advantage and outscored the Demon Deacons 46-14 in the paint in beating them for the 34th straight time.
Wake Forest (12-14, 3-7) scored just 13 points during the final 17½ minutes and was held to a season-low point total. It lost for the seventh time in 10 outings and hasn't beaten Duke since the 1993 ACC tournament.
Chelsea Gray finished with 10 points for Duke, which held the Demon Deacons scoreless for nearly seven minutes in the second half while scoring 12 straight points during a 31-5 run that made it a 40-point game.
Meanwhile, Wake Forest managed only one field goal in a 12½-minute stretch — a layup by Brittany Waters with 11 minutes left. After Sandra Garcia's layup with 17:59 remaining, the Demon Deacons were 3 of 19 the rest of the way.
The Blue Devils had been stewing since Monday night's 62-60 loss to rival North Carolina in which they could have forced overtime had Gray's layup at the buzzer not been blocked. That marked their second loss in three games, after a 20-0 start had left them as the nation's last unbeaten team.
Looking to avoid their first losing streak since 2007, the Blue Devils shot 50 percent while relying almost exclusively on high-percentage shots from close range to once again take care of the Demon Deacons.
When this game was at its closest, Duke simply dominated the interior at both ends of the floor. All but two of its 16 field goals in the first half came in the paint.
Duke used an early 16-6 run midway through the half to push its lead into double figures, then reeled off eight consecutive points during a 15-6 run that closed the half. Krystal Thomas had 10 points and six rebounds at the break, and Jasmine Thomas' 3-pointer with 15 seconds left made it 38-21.
Chelsea Douglas scored 11 points for Wake Forest, which hasn't beaten Duke in Winston-Salem since 1991.