A day after Duke's third-ranked men were routed in New York, the school's third-ranked women met a similar fate a bit further north.
Maya Moore scored 29 points and No. 2 Connecticut beat the Blue Devils 87-51 on Monday night, handing Duke its first loss of the season.
The senior All-American also grabbed nine rebounds and dished out seven assists for the Huskies (21-1), who opened the game on a 23-2 spurt and ran away from the Blue Devils (20-1).
"We knew we had to have a really good start, because when you have a really good team in your place, you don't want them to think they can get in the game," Moore said.
Tiffany Hayes added 20 points for the Huskies, who have won 73 consecutive home games. It was UConn's ninth straight victory since having its record 90-game win streak snapped in a loss to Stanford on Dec. 30.
Kelly Faris had 14 points and Stefanie Dolson added eight points and 12 rebounds.
It wasn't what UConn coach Geno Auriemma was expecting.
"A couple of times I looked up at the scoreboard and I couldn't believe what the score was," he said.
Jasmine Thomas had 13 points to lead Duke, which was making its first visit to Gampel Pavilion. She hit just four of her 16 shots.
"Connecticut came out punching and we just completely stepped back or took the punches," Duke coach Joanne P. McCallie said. "We didn't do anything to counterpunch or to fight back early and that's the way it went."
The loss came a day after Mike Krzyzewski's men's team lost to St. John's 93-78.
Connecticut opened the game by pressing on defense. Duke missed its first 12 shots, including six 3-pointers, and the Huskies jumped out to a 13-0 lead. Shay Selby's layup just more than 5 minutes into the game got the Blue Devils on the board.
They didn't score again until Karima Christmas hit a free throw with less than 9 minutes left in the half, and by that time UConn was up 23-3.
The Blue Devils hit just one of their first 20 shots from the floor and were 1 of 10 from behind the arc.
A lob pass from Lorin Dixon to Moore made it 38-9 Huskies, sending the already excited crowd into a frenzy. It was 40-9 when the students began chanting "Overrated!" at the Duke bench.
The Blue Devils shot less than 16 percent from the floor in the first half and the Huskies went into halftime up 41-15.
Duke, which rallied from a 20-point deficit to beat North Carolina State on Jan. 23, opened the second half in a trapping press defense and went on a 14-7 run.
The Blue Devils cut the UConn lead to 50-32 on Krystal Thomas' layup. But UConn responded with an 11-0 run, capped by a 3-pointer by Moore from the top of the key.
The Huskies pushed the lead to 36 in the second half.
Duke finished with only 19 field goals and shot just 28 percent from the floor. UConn outrebounded Duke 49-28.
"We didn't compete," Thomas said. "We dug ourself in a hole and then didn't fight hard enough and stay together to get out of it."
It was Moore's 134th game in double figures, tying a record set by Courtney Paris at Oklahoma.
"When you have an athlete like Maya, the second she steps off the floor, you are kind of waiting for her to come back in," Faris said. "It's fun being on the floor with her. I can speak for everybody that when she's on the floor, she kind of relaxes us all."
The Huskies' last home loss came in March 2007, a 55-47 defeat in the Big East Tournament championship game. The NCAA considers Big East and NCAA tournament games played at Gampel Pavilion and the XL Center as home games.