Tyreek Duren scored six of his 12 points in the second overtime as La Salle rallied from an eight-point halftime deficit to beat Charlotte 91-86 on Saturday night.
Jerrell Williams and Earl Pettis had 17 points each, Aaric Murray added 16 points and Ruben Guillandeaux had 12 for the Explorers (11-11, 3-4 Atlantic 10 Conference), who won their third straight game.
K.J. Sherrill had a career-high 24 points and 13 rebounds for the 49ers (9-12, 1-6), who lost for the third straight time and the sixth time in their past seven games.
Javarris Barnett added 19 points, Jamar Briscoe scored 14 and An'Juan Wilderness and Derrio Green had 11 points each for Charlotte, which led 35-28 at the half and 67-61 with 1:10 remaining in regulation.