Devereaux Peters and Kayla McBride scored 14 points each as No. 12 Notre Dame cruised to an 80-60 victory over Louisville on Wednesday night.
Skylar Diggins and Natalie Novosel scored 12 points each and Brittany Mallory and Becca Bruszewski added 11 each for the Irish (14-4, 3-1 Big East).
Asia Taylor had 16 points for Louisville (12-6, 3-1). Shoni Schimmel scored 11 and Monique Reid added 10.
Notre Dame used a 16-2 run to close the first half and take a 37-22 lead at the break.
Peters, who had sat out 10 minutes of the first half, scored eight points as the Irish opened the second half with an 11-2 run to take a 24-point lead. Their biggest advantage was 29 with 6:08 to go.
Neither team could establish much in the first 8 minutes of play. McBride hit a 10-footer to start an 8-1 run by that gave Notre Dame a 17-13 lead with 9 minutes to go in the half.
Louisville shot around 30 percent for much of the game before finishing at 34 percent (21 for 61) — including 4 for 17 on 3-pointers. Notre Dame was at 47 percent (26 for 55) overall and 4 for 10 on 3s.