Polamalu has an injured right Achilles' tendon and hasn't played or practiced for two weeks. Coach Mike Tomlin said he won't practice Wednesday or Thursday.
If Polamalu can't go on Friday, he won't play against the Browns.
Quarterback Ben Roethlisberger's broken nose isn't considered to be a problem, even though it was bloodied by a hit during Pittsburgh's 27-3 win over Carolina on Thursday.
Tomlin also said Tuesday that running back Mewelde Moore is questionable because of a sprained right knee. Linebackers LaMarr Woodley and Jason Worilds also have swelling in the knee, and cornerback Bryant McFadden has a hip injury.