Bengals receiver Terrell Owens left Sunday's game against the Browns after aggravating his sore left knee.

The 37-year-old receiver missed practice last week because of the knee, but was on the field for the opening drive. He ran a long pass route on Cincinnati's sixth play, then hobbled off the field. The Bengals said he wouldn't return.

The injury was a major setback for the Bengals. Owens had a huge game in a 23-20 loss in Cleveland earlier in the season, catching 10 passes for 222 yards — the second-highest total of his career. He became the oldest receiver in NFL history to have 200 yards receiving.

Third-year receiver Jerome Simpson was active for the game, only the fourth time this season he was active.