Brown had surgery in the offseason on his right knee as he rehabilitated and missed most of the preseason. The past few weeks, he has been playing despite not being able to practice. He started 11 games but was inactive for two with 3½ sacks and 10 quaraterback pressures.
The Titans (5-8) ended Brown's season Wednesday.
They replaced Brown on the roster by signing center Kevin Matthews off the practice squad. Matthews is the son of Hall of Fame lineman Bruce Matthews, currently an assistant coach with the Houston Texans.