Mario Williams, the Houston defensive end who went to the last two Pro Bowls, is out for the rest of the season.
The Texans said Wednesday that Williams had been placed on season-ending injured reserve. He's struggled with injuries since September, and a groin injury was listed as the reason.
The team also placed wide receiver David Anderson (shoulder) and guard Mike Brisiel (calf) on injured reserve.
The Texans (5-8) play at Tennessee (5-8) on Sunday. If AFC South rival Jacksonville wins just one of its last three games, Houston will be eliminated from postseason contention for the ninth straight year.