DeAndre Liggins scored a career-high 19 points, Brandon Knight added 18 points and six rebounds and No. 17 Kentucky bulled its way past Indiana, 81-62, on Saturday.
Josh Harrellson added 14 points and 12 rebounds for the Wildcats (7-2), who continued their dominance in the once-heated rivalry by shutting down the Hoosiers in the second half.
Indiana (7-2) managed just one field goal in the final 10 minutes as Kentucky closed with a 25-5 burst after the Hoosiers had taken a 57-56 lead.
Christian Watford led Indiana with 19 points and nine rebounds but the Hoosiers fell to their border rivals for the 14th time in the last 17 meetings.
Indiana made the Wildcats work for it in a rugged game that featured 47 fouls, a number of which sent bodies tumbling to the ground.