E'Twaun Moore scored 23 points to help No. 19 Purdue beat Valparaiso 76-58 on Tuesday night.
JaJuan Johnson had 13 points, eight rebounds and four blocks, Kelsey Barlow scored 13 points and Lewis Jackson added 11 points, four assists and four steals for the Boilermakers (8-1), who won their third straight.
It was Purdue's first game without John Hart. The team's No. 3 scorer is expected to miss at least a month with a stress fracture in his right foot.
Purdue led 30-28 at halftime before shooting 57 percent from the field after the break.
Brandon Wood scored 20 points for Valparaiso (6-3), but he had just two in the second half. Wood made 7 of 11 shots from the field, but his teammates made just 13 of 41.
The Crusaders had averaged 76 points per game, but they shot 39 percent had committed 16 turnovers.
Purdue's last on-court loss to its intrastate rival had come in 1965, but the Boilermakers struggled early.
Wood's 3-pointer with 5 minutes left in the first half gave the Crusaders a 25-23 lead and got the capacity crowd into a frenzy.
Purdue hung tough, and a bank shot by Johnson gave the Boilermakers a two-point lead at halftime. The preseason All-American had five points, four rebounds and four turnovers at the break while struggling against Valparaiso's double teams.
Wood made his first seven shots and scored 18 points in the first half.
Moore hit a 3-pointer from the right wing, then made a jumper from inside the arc to give the Boilermakers a 38-34 lead three minutes into the second half. A 3-pointer by Ryne Smith put the finishing touch on an 8-0 run.
Valparaiso closed within four before the Boilermakers began pulling away. Moore tipped in his own miss to put the Boilermakers up 53-40, and Purdue led by double digits the rest of the way.