Jarrett Jack had 16 points and Andrea Bargnani, Leandro Barbosa and Jose Calderon all scored 12 for the Raptors (1-5), who finished a tough four-game West Coast trip winless and have lost five straight to Portland.
Nicolas Batum (20 points), Andre Miller (13 assists) and Marcus Camby (16 rebounds) all had season highs for the Blazers, who are 5-2 despite a recent spate of injuries. Camby started despite suffering from migraines in recent days. He was sent home from Saturday's shootaround to rest and briefly left for the locker room for a time in the second quarter.
Power forward Aldridge started after sitting out Friday's practice with a sore knee. Guard Rudy Fernandez missed his second straight game with a back problem and rookie guard Elliot Williams was lost for the season Thursday with a knee injury.
Journeyman forward-center Sean Marks, signed Saturday to bolster Portland's front line, entered the game in the first quarter and played 10 minutes. Marks took the roster spot of Fabricio Oberto, who retired Thursday with a heart condition. The Blazers are already without injured centers Greg Oden and Joel Przybilla, both out with knee injuries.
The Raptors, who fell 108-103 to the Los Angeles Lakers on Friday night, looked like a team playing a back-to-back. They shot just 37 percent and made 1-of-17 3-pointers. DeMar DeRozan and Leandro Barbosa had no luck keeping Roy from getting to the basket. DeRozan was 1 for 10 and had just two points.
Bargnani was really the only Raptor who played well for the first 2½ quarters. At one point midway through the third, the former No. 1 overall pick was 6 of 12 from the field, while his teammates were a combined 8 of 35.
The outcome seemed assured after the Blazers went on a 20-5 run to make it 69-46 in the third quarter, but Toronto did show signs of life late in the period, with Barbosa and Julian Wright keying a 19-4 run which got the Raptors within 73-65.
However, the Blazers answered with a 17-4 run of their own to put away the game. Bargnani missed his last five shots.
Notes: Toronto shot just 28 percent in the first half. ... The Blazers were 25 of 28 from the free throw line. ... Roy passed former forward and current assistant coach Buck Williams to move into 15th place on the Blazers' career scoring list.