Stephen Curry added 16 points before re-injuring his right ankle in the third quarter. The second-year guard, who originally hurt the ankle in the preseason and aggravated it in the Warriors' season-opening victory against Houston on Wednesday night, did not return.
Ellis, who matched his career high of 46 points against the Rockets, had an off night shooting, but made three 3-pointers and came within two assists of tying his personal best.
Blake Griffin, the top overall pick in 2009 who missed all of last season because of a knee injury, had his second straight double-double with 14 points and 10 rebounds while playing in foul trouble most of the second half.
The Warriors are 2-0 for the first time since 1994 when they won their first five before finishing 26-56.
Golden State's good feelings after the game were tempered by the injury to Curry, who was hurt while trying to get around a pick set by Griffin with 6:03 left in the third quarter.
Curry rolled his right foot and immediately fell to the floor in pain. When play was halted, trainers rushed out to Curry, who lay on the court for several moments while surrounded by teammates and coach Keith Smart.
Curry eventually was helped to his feet and limped slowly off the court. He was examined in the trainer's room and did not return.
Before getting hurt, Curry scored six straight points to start the third quarter and ignited a 21-2 run that put Golden State ahead for good. Ellis had five points during the streak while Lee added four, then later scored on a three-point play to give the Warriors their biggest lead of the night at 87-63.
Wright helped pick up the scoring slack once Curry left, matching his career high with six 3-pointers.
Griffin did most of his scoring in the first quarter before heading to the bench with three fouls. He finished 6 of 14 from the floor and added three assists for the Clippers (0-2).
Ellis notched his 15th career double-double for Golden State, which beat Los Angeles for the ninth time in the last 10 games between the two teams at Oracle Arena.
Golden State only led 58-54 at halftime despite outshooting Los Angeles.
The Warriors made their first eight shots and didn't miss until nearly 8 minutes into the first quarter. The Clippers started 6 of 18 but shrugged off the slow start and used a 12-0 to build a 28-27 lead.
Griffin, who had 20 points and 14 rebounds against Portland in the Clippers' opener, scored seven points in the first quarter but was shut out in the second when he played less than 2 minutes after picking up his third foul.
NOTES: The game was the 5,000th in Warriors' franchise history. The team is 2,295-2,2705 in that span. ... It was Asian Heritage Night at Oracle Arena and the crowd of 17,408 rose in a standing ovation when reserve Jeremy Lin checked into the game with 2:32 remaining in the fourth quarter. Lin, who grew up in the Bay Area, didn't score but hustled for a loose ball that brought the crowd to its feet again.