Carlos Lee hit a three-run homer in the eighth inning to power the Houston Astros to a 4-1 win over the Pittsburgh Pirates on Friday night.
Houston was down before Lee connected against All-Star reliever Evan Meek (4-4), belting a drive to the Crawford Boxes in left. Angel Sanchez hit a one-out single and Hunter Pence walked before Lee's 15th homer.
The Astros kept going after Lee's go-ahead shot, putting together three consecutive singles. Rookie Brett Wallace's hit scored Geoff Blum to make it 4-1.
The Pirates wasted a great start by Ross Ohlendorf in their fifth consecutive loss, dropping to a major league-worst 39-76.
Wilton Lopez (4-0) allowed one hit in a scoreless eighth inning and Brandon Lyon finished for his third save.
Pittsburgh went ahead in the third inning against Brett Myers. Andrew McCutchen singled, stole second and moved to third on Jose Tabata's grounder. Neil Walker then drove him with a single to center.
Myers pitched seven innings and has lasted at least six innings in each of his 24 starts, extending his franchise record to start a season. He allowed seven hits, struck out seven and walked none.
Ohlendorf was even better, pitching 6 2-3 innings of four-hit ball. But he remains winless in 10 appearances against the Astros.
Ohlendorf allowed a pair of singles with one out in the first inning before walking Lee to load the bases. He pitched out of that jam by striking out Blum before Chris Johnson popped out to end the inning.
He retired 11 of the next 12 batters before walking Michael Bourn with two outs in the fifth. Bourn stole second but was stranded when Ohlendorf struck out Sanchez.
Pedro Alvarez had three hits, a pair of singles and a ground-rule double, for the Pirates. Ohlendorf struck out seven and walked two.
NOTES: Pittsburgh SS Ronny Cedeno was sidelined with inflammation in his left shoulder. He doesn't think it's serious and expects to return soon. ... Tests performed on Houston closer Matt Lindstrom's bothersome back showed no structural damage. He was given medication and hopes that combined with treatment will eliminate the problem. ... Houston RHP Felipe Paulino was examined by Dr. James Andrews for a second opinion on his injured right shoulder. Andrews agreed with the first diagnosis of a rotator cuff strain and recommended continued rest and treatment. Paulino has been on the disabled list since June 21.