Choo was injured while attempting a diving catch on Jack Cust's double in the eighth inning Friday night. His glove hand appeared to bend awkwardly when he hit the ground. Choo was removed in the top of the ninth.
Cleveland manager Manny Acta said Choo would have an MRI this weekend.
Choo is hitting .286 with 13 homers and 43 RBIs in 78 games. He could be Cleveland's only All-Star representative when the teams are announced Sunday.