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SAN DIEGO (AP) — Will Venable hit a three-run homer, dashing Jake Arrieta's bid to win his first three big league starts, and the San Diego Padres rallied from a four-run deficit in the first inning to beat the Baltimore Orioles 9-4 on Sunday.

Venable tied his career high with four RBIs and Nick Hundley homered and drove in three runs for the NL West leaders, who took two of three from the struggling Orioles.

Baltimore (19-50), which has the worst record in the majors, hasn't won consecutive games since winning three straight from May 12-14. The Orioles are 0-10-1 in road series this year.

Jon Garland and three relievers combined on a six-hitter for San Diego. Garland (7-5) retired his last 14 batters and snapped a three-start losing streak. The Orioles had only two baserunners after the second.

The Orioles led 4-3 in the third when Venable drove a hanging pitch from Arrieta down the right-field line with one out to put the Padres up by two. It was his fifth home run. David Eckstein opened the inning with a double and scored on Hundley's one-out single. Scott Hairston walked ahead of Venable's homer.

Arrieta (2-1) was gone after three innings, having given up five earned runs and five hits while walking three and striking out none. The prized rookie beat the New York Yankees 4-3 in his big league debut June 10, pitching six innings of four-hit ball. He won 4-1 at San Francisco on Tuesday

Venable added an RBI single in the fifth off Mark Hendrickson.

Hundley hit a two-run homer off Frank Mata in the seventh, his fifth. Adrian Gonzalez was aboard on his third double, which tied his career high. Gonzalez scored twice and drove in a run. The two-time All-Star has hit safely in 17 of 20 games, raising his average from .261 to .310.

Garland allowed four runs and five hits in six innings, struck out three and walked two.

Baltimore scored four runs in the first. After Garland loaded the bases by allowing two singles and a walk, Adam Jones hit a routine grounder to third. Lance Zawadzki hesitated before throwing to first, allowing Jones to reach and Corey Patterson to score. Zawadzki originally was charged with an error, but the official scorer changed it to a single after the game. Matt Wieters then cleared the bases with a three-run double to left-center.

NOTES: There were three Hall of Famers at the ballpark: Orioles broadcasters Jim Palmer and Eddie Murray, and former San Diego great Tony Gwynn, who spent Father's Day watching his son, Tony Jr., play for the Padres. ... Padres 3B Chase Headley, who's struggling at the plate, got the day off. ... San Diego OF Matt Stairs, on the disabled list with a strained right knee, probably will take batting practice Tuesday but won't be ready to play in a three-game series at Tampa Bay. ... SS Everth Cabrera, on the DL for the second time this season with a strained right hamstring, could be ready to return in three days. ... Padres reliever Luke Gregerson walked Wieters leading off the seventh to snap his streak of 110 batters faced without issuing a walk. That was a record for Padres relievers and the most by a San Diego pitcher since Greg Maddux went 244 batters without allowing a walk from July 28 to Sept. 18, 2007.