Arroyo allowed 10 runs and 11 hits in four innings. The right-hander's error in the third led to five unearned runs.
Lou Marson hit a three-run homer in the fourth for Cleveland. The rookie, one of four players acquired in the July trade that sent Cliff Lee to Philadelphia, will share the catching duties with veteran Mike Redmond.
Triple-A right-hander Yohan Pino started for Cleveland and gave up three runs and three hits over 4 2-3 innings, including Brandon Phillips' solo homer in the second inning.