The Red Sox scored two runs in the eighth inning off Twins reliever Ron Mahay. Scott Schoenweis pitched a scoreless eighth for the Red Sox.
John Lackey went five innings and gave up six hits, including a homer to Jim Thome. He walked six and struck out two.
Nick Blackburn, making his fifth appearance and third start, went five innings, giving up three runs and five hits with two strikeouts.
Marco Scutaro went 2 for 3 with two RBIs for the Red Sox.