After pitching three scoreless innings, Harden couldn't escape the fourth, leaving with two outs after giving up a double, triple, home run and walked in a run. Harden allowed six runs on seven hits and three walks in 3 2-3 innings.
Hairston and Adrian Gonzalez each had two hits for the Padres.
Padres starter Sean Gallagher also had a tough day, surrendering five runs in the third inning.
Gallagher didnt walk a batter but allowed five hits over four innings, including a three-run homer to Nelson Cruz.
Michael Young also had two hits for Texas.