Durant was 7 of 16 from the field and 17 of 18 from the free-throw line.
Jeff Green added 25 points, and Russell Westbrook had 11 points and 10 assists for the Thunder, fifth in the Western Conference at 42-25.
Chris Bosh led Toronto with 22 points and 10 rebounds, and Andrea Bargnani had 15 points. The Raptors, eighth in the Eastern Conference with 15 games left, are 2-10 in their last 12 games and 33-34 overall.
Durant scored 23 points in the first half to take a 71-44 lead. Oklahoma City stretched the advantage to 34 in the second half on Green's 3-pointer.
The fans at Air Canada Centre stood and booed as the game ended.
NOTES: Bosh had four of Toronto' 19 turnovers. ... Kyle Weaver, recalled recently from Tulsa of the NBA Development League, had 12 points for Oklahoma City.