Lowrie has not played since March 11 and had been feeling fatigued. He went for tests this week.
"He can play as tolerated," Red Sox manager Terry Francona said Wednesday. "There's a reason he was feeling run down last week. He was on the bike yesterday. I don't think he's going to feel like he has a ton of energy for the next whatever, week or two. But he can do physical things as tolerated. So we'll monitor him. I don't think we want him kissing anybody, but we'll keep an eye on him."
Lowrie was Boston's opening-day shortstop last season but got off to a 1-for-18 start at the plate after playing with an injured left wrist for much of the second half of the 2008 season, He had surgery April 21, nine days after going on the disabled list, and didn't return to the Red Sox until July 18.
He went back on the DL Aug. 18 because of an irritated left forearm and wasn't activated until Sept. 8. He wound up hitting .147 with two homers and 11 RBIs in 32 games for Boston.