The Anaheim playmaker is scheduled to suit up for Canada at his first Olympics next week, but coach Randy Carlyle said Getzlaf would leave the Honda Center on crutches with his foot in a protective boot.
"Hopefully, he won't be out too long," said defenseman Scott Niedermayer, the captain of the Ducks and Team Canada. "I don't have to say what he means to this team and what he does for us, so hopefully it's not bad."
Getzlaf scored his 15th goal earlier in the game before spraining his ankle and hobbling to the bench, apparently getting hurt behind the play. He didn't return to action.
X-rays on Getzlaf's ankle revealed no broken bones, and he's expected to undergo an MRI on Tuesday.
Getzlaf has 57 points in 55 games for the Ducks, earning his Olympic selection alongside Canadian teammates Scott Niedermayer and Corey Perry, who had a goal and two assists in Anaheim's 4-2 win over the Kings, their 10th straight victory at home.
"I haven't really thought about (the Olympics), to be honest," Niedermayer said. "I know he would love to play, but we don't know how badly hurt he is right now. Hopefully he's in our lineup in two nights (against Edmonton)."