The tournament will take place from April 8-11 at the Pun Hlaing Golf Club and offer a total purse of $300,000.
"As a player-led organization the Asian Tour will continue to grow the game across the region," Asian Tour executive chairman Kyi Hla Han, himself from Myanmar, said.
Myanmar's most recognizable player Zaw Moe said the tournament would help boost the standard of golf in the country.
"It's always special to play in front of your home fans," said the 1997 Singapore Open champion. "I'm looking forward to it and I will be ready to give my best."
Australian Scott Strange won the last Myanmar Open in 2005.
(Reporting by Alastair Himmer in Tokyo. Editing by Patrick Johnston)