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MAVEN is heading for Mars.

NASA's MAVEN spacecraft blasted off aboard an unmanned Atlas V rocket at 1:28 p.m. EST Monday afternoon from Cape Canaveral Air Force Station on a long journey into space. Its ultimate destination: Mars.

"Go Atlas. Go Centaur. Go MAVEN," Mission Control said, mere seconds before the rocket soared into blue skies dotted with wispy clouds over the launchpad.

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NASA managers had loaded 50,000 gallons of liquid oxygen fuel into a Centaur rocket in the early afternoon prior to giving the "go" that signaled readiness for the space agency's newest Martian explorer. The mission received warm wishes from colleagues who had already left the grasp of Earth's gravitational pull.

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"From the International Space Station, best wishes for a fabulous mission," said flight engineer Mike Hopkins from aboard the orbiting space base in the minutes before the launch.

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NASA is sending Maven to Mars to study its upper atmosphere. Scientists want to know why Mars went from being warm and wet during its first billion years, to the cold and dry place it is today.

The early Martian atmosphere was thick enough to hold water and possibly support microbial life. But much of that atmosphere may have been lost to space, eroded by the sun.

"Something clearly happened," the University of Colorado's Bruce Jakosky, the principal Maven scientist, said on the eve of Maven's flight. "What we want to do is to understand what are the reasons for that change in the climate."

Maven -- bearing eight science instruments -- will take 10 months to reach Mars, entering into orbit around the red planet in September 2014. The mission costs $671 million.

A question underlying all of NASA's 21 Mars missions to date is whether life could have started on what now seems to be a barren world.

"We don't have that answer yet, and that's all part of our quest for trying to answer, 'Are we alone in the universe?' in a much broader sense," said John Grunsfeld, NASA's science mission director.

Maven stands for Mars Atmosphere and Volatile Evolution, with a capital "N" in EvolutioN.

It is NASA's 21st shot at Mars. Fourteen of the previous 20 missions have succeeded, the most recent being the Curiosity rover that was launched in 2011 and landed in 2012.

That's a U.S. success rate of 70 percent. No other country comes close.

Curiosity's odometer reads 2.6 miles after more than a year of roving. An astronaut could accomplish that distance in about a day on the Martian surface, Grunsfeld noted Sunday.

Grunsfeld, a former astronaut, said considerable technology is needed, however, before humans can fly to Mars in the 2030s, NASA's ultimate objective.

The Associated Press contributed to this report.