John McCain apologized Tuesday for disparaging comments about Barack Obama made by talk radio host Bill Cunningham at a McCain campaign rally in Cincinnati.

Cunningham, a radio host at WLW-AM, had warmed up the crowd at Memorial Hall with comments about Obama and Hillary Clinton, likening Obama to a "hack, Chicago-style" politician and saying the Illinois senator would "saddle up next to Hezbollah," Iranian President Mahmoud Ahmadinejad and North Korean leader Kim Jong Il if elected president.

When McCain addressed the crowd, he apologized for the remarks. "I regret any comments that may be made about these two individuals (Obama and Clinton) who are honorable Americans," he said. "We just have strong philosophical differences, and so I want to disassociate myself from any disparaging remarks that may have been said about them."

Though McCain apologized for remarks directed at both Democratic presidential candidates, Cunningham's comments were directed at the Obama camp.

Cunningham had delivered remarks that painted a grim future for America if "Barack Hussein Obama" is elected president. He mentioned Obama's middle name three times.

"Obama just came back from meeting Ahmadinejad; he's got a meeting the next week with Kim Jong Il of North Korea. Then he's going to saddle up next to Hezbollah; they're going to have a little cookie-and-cream party. All's going to be right with the world.

"When the great prophet from Chicago takes the stand, and the world leaders who want to kill us will simply be singing 'Kumbayah' together around the table of Barack Obama, it's all going to be great," Cunningham said. "Things are going to be wonderful."

Cunningham ended his stump speech with "if you think about immigration, think about terror, think about success in Iraq, there is only one man who can get the job done, John 'Wayne' McCain for president."

McCain later took the stage and apologized for the remarks.

"I will take responsibility in any offense that was inflicted," the Arizona senator said.

Asked whether the use of Obama's middle name — the same as former Iraqi leader Saddam Hussein — is proper, McCain said: "No, it is not. Any comment that is disparaging of either Senator Clinton or Senator Obama is totally inappropriate."

McCain said he didn't know who decided to allow Cunningham to speak, but he said he was sure it was in coordination with his campaign. He said he didn't hear the comments and has never met Cunningham, but "I will certainly make sure that nothing like that happens again."

Bill Burton, a spokesman for the Obama campaign, applauded McCain's remarks.

"It is a sign that if there is a McCain-Obama general election, it can be intensely competitive but the candidates will attempt to keep it respectful and focused on issues," Burton said.

Last fall, McCain faced criticism for not immediately repudiating a voter in South Carolina who called Clinton a "bitch." McCain chuckled in response to the voter's question, but didn't embrace the epithet. A few minutes later, he said he respected Clinton, a New York senator and colleague.

At one point on Tuesday, Cunningham compared Secretary of State Condoleezza Rice to Madeleine Albright, who he said "looks like death warmed over." He also commented on the difference between former Ohio Rep. Rob Portman, whose wife is named Jane, and Massachusetts Rep. Barney Frank, who is gay. "Jane's the main difference. But that's a different story," Cunningham said.

As Cunningham finished, Portman, who has been mentioned as a possible vice presidential candidate, took the microphone to introduce McCain.

"Willie, you're out of control again. So, what else is new? But we love him," Portman said. "But I've got to tell you, Bill Cunningham lending his voice to this campaign is extremely important. He did it in 2000, he did it in 2004. It was crucial to victory then and it's even more important this year with his bigger radio audience. So, Bill Cunningham, thank you for lending your voice."

Speaking to reporters later alongside McCain, Portman said: "I was backstage so I didn't hear everything he said. Bill Cunningham is a radio talk show host who is often controversial so it does not surprise me that he was controversial." He added: "That's, I guess, how he makes his living."

The Associated Press contributed to this report.