Republicans are readying themselves for the first Democratic primary debate Tuesday with a comprehensive response strategy that includes a brand new attack ad targeting two-time presidential hopeful Hillary Clinton.

The ad, released Monday by the Republican National Committee, pays special attention to a comment made by Clinton in August with regards to the private email server she kept during her tenure as Secretary of State.

"Most importantly I never sent classified material on my email and I never received any that was marked classified," Clinton told reporters at the Iowa State Fair at the time.

Federal agencies reviewing the content of the former secretary of state's emails have since marked hundreds as containing classified content.

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