Rep. Dave Camp, chairman of the powerful tax-writing House Ways and Means Committee, will not seek re-election in the fall.
The Michigan Republican said Monday he decided not to run this year "after much consideration and discussion with my family."
"Serving in Congress is the great honor of my professional life," said Camp, who has been in Congress since1991. "I am deeply grateful to the people of the 4th Congressional District for placing their trust in me. Over the years, their unwavering support has been a source of strength, purpose and inspiration."
Camp is the second committee chairman from Michigan to announce he is leaving Congress since last week. On Friday, House Intelligence Committee Chairman Mike Rogers, R-Mich., said he would not seek re-election.
Camp said about his outstanding business on Capitol Hill: "During the next nine months, I will redouble my efforts to grow our economy and expand opportunity for every American by fixing our broken tax code, permanently solving physician payments for seniors, strengthening the social safety net and finding new markets for U.S. goods and services."
He battled non-Hodgkin's lymphoma, underwent chemotherapy and said he was cancer-free in December 2012.
Camp was term-limited as chairman of the tax-writing committee.
Last month, he unveiled a far-reaching plan to overhaul the nation's tax laws that would wipe out a slew of popular tax breaks to help pay for lower overall tax rates. It would repeal deductions for state and local taxes, medical expenses and moving expenses. Tax credits for child care, adoption services and energy-efficient upgrades to homes would be gone as well.
"We need to be the party of growth, opportunity, restoring the American dream. And I think this is something Americans have hungered for," said Camp, the plan's author.
The proposal got a chilly reception from Democrats and Republicans.
"Any proposal that eliminates the deduction for state and local taxes, as the Republican plan would do, is dead on arrival," said Sen. Chuck Schumer, D-N.Y.
House Speaker John Boehner, R-Ohio, has declined to promise a vote on it this year.
“Dave Camp and I were elected to the House the same year,” Boehner said Monday.“From the beginning, I have been impressed by his wisdom and thoughtfulness … .He has been a leader in the fight to increase economic growth and help create more American jobs by reforming our tax code, pushing for more effective free trade agreements and saving Social Security and Medicare for future generations.”
Republicans are expected to hold Camp's GOP-leaning seat in central Michigan.
Camp’s retirement makes him the 23rd House member retiring from this Congress -- 10 Democrats and 13 Republicans.
His departure also marks the eighth committee chairmen in Congress who is retiring -- four in the House and four in the Senate.
Fox News’ Chad Pergram and The Associated Press contributed to this report.