Rove and his wife Darby were married in January 1986. They have one son.
Family spokesperson Dana Perino said Rove and his wife "came to the decision mutually and amicably."
A Rove family friend told Politico the couple spent Christmas together with their son and remain friends.
Rove's 600-plus page memoir, "Courage and Consequence: My Life as a Conservative in the Fight," is due to be released in March.