The diet drug Alli is the only FDA-approved over-the-counter weight loss drug. It works by blocking some of the fat you eat. BUT, users have to reduce their fat intake while using. Why? The drug causes the fat you don’t absorb to pass directly out of the body, which means that if you eat too much fat you may wind up with the unpleasant side effects of gas with oily spotting, loose stools, and more frequent stools that may be hard to control.

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